amlodipine, hydrochlorothiazide, and olmesartan

Browse By All Topics

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

amlodipine, hydrochlorothiazide, and olmesartan

Pronunciation:am LOE di peen, HYE droe KLOR oh THYE a zide, and OL me SAR tan
Brand:Tribenzor

What is the most important information I should know about amlodipine, hydrochlorothiazide, and olmesartan?

nopregDo not take this medication if you are pregnant. Stop using the medication and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
donotYou should not use this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic), or olmesartan (Benicar), or if you have severe kidney disease, if you are unable to urinate, or if you are allergic to sulfa drugs.

Before you take amlodipine, hydrochlorothiazide, and olmesartan, tell your doctor if you have kidney or liver disease, congestive heart failure, angina (chest pain), severe coronary artery disease, glaucoma, lupus, diabetes, a penicillin allergy, if you are dehydrated, or if you are vomiting or having diarrhea.

nobrfeedYou should not breast-feed while you are taking this medication.

Call your doctor at once if you have any signs of an electrolyte imbalance, such as: headache, trouble concentrating, memory problems, weakness, feeling unsteady, nausea, loss of appetite, extreme thirst, increased urination, leg discomfort, jerking muscle movements, muscle weakness or limp feeling, shallow breathing, uneven heart rate, confusion, feeling tired or restless, hallucinations, fainting, or seizure.

What is amlodipine, hydrochlorothiazide, and olmesartan?

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Olmesartan is an angiotensin II receptor antagonist. Olmesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of amlodipine, hydrochlorothiazide, and olmesartan is used to treat high blood pressure (hypertension). This medication is usually given after others have been tried without successful treatment of hypertension.

Amlodipine, hydrochlorothiazide, and olmesartan may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking amlodipine, hydrochlorothiazide, and olmesartan?

donotYou should not use this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic), or olmesartan (Benicar), or if you have:
  • severe kidney disease;
  • if you are unable to urinate; or
  • if you are allergic to sulfa drugs.

To make sure you can safely take amlodipine, hydrochlorothiazide, and olmesartan, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • angina (chest pain), severe coronary artery disease;
  • glaucoma;
  • lupus;
  • diabetes;
  • a penicillin allergy;
  • if you are dehydrated; or
  • if you are vomiting or having diarrhea.
nopregFDA pregnancy category D. Do not take amlodipine, hydrochlorothiazide, and olmesartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking this medication.
nobrfeedIt is not known whether amlodipine, hydrochlorothiazide, and olmesartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking this medication.

How should I take amlodipine, hydrochlorothiazide, and olmesartan?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Amlodipine, hydrochlorothiazide, and olmesartan is usually taken once per day. Follow your doctor's instructions.

This medication may be taken with or without food.

emtYou may have new or worsening chest pain when you first start taking amlodipine, hydrochlorothiazide, and olmesartan or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

rtStore at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness, fast or slow heartbeat, or fainting.

What should I avoid while taking amlodipine, hydrochlorothiazide, and olmesartan?

donotDo not use potassium supplements or salt substitutes while you are taking amlodipine, hydrochlorothiazide, and olmesartan, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

noalcoholDrinking alcohol can further lower your blood pressure and may increase certain side effects of this medication.

What are the possible side effects of amlodipine, hydrochlorothiazide, and olmesartan?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donotCall your doctor at once if you have any other serious side effects, such as:
  • eye pain, vision problems;
  • feeling like you might pass out;
  • swelling in your hands, ankles, or feet;
  • urinating less than usual or not at all;
  • pain or burning when you urinate;
  • joint pain or swelling with fever, swollen glands, muscle aches, unusual thoughts or behavior, patchy skin color, red spots, or skin rash on your face;
  • headache, trouble concentrating, memory problems, weakness, feeling unsteady, hallucinations, fainting, seizure, shallow breathing;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
  • electrolyte imbalance--nausea, loss of appetite, uneven heart rate, extreme thirst, increased urination, leg discomfort, jerking muscle movements, muscle weakness or limp feeling, confusion, and feeling tired or restless.

Less serious side effects may include:

  • dizziness;
  • diarrhea;
  • muscle spasms;
  • cold symptoms such as stuffy nose, sneezing, sore throat; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amlodipine, hydrochlorothiazide, and olmesartan?

Tell your doctor about all other medicines you use, especially:

  • other medications that lower blood pressure;
  • heart medication or another diuretic (water pill);
  • potassium supplements or salt substitutes;
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • insulin or oral diabetes medication;
  • lithium (Eskalith, LithoBid);
  • simvastatin (Zocor, Simcor, Vytorin, Juvisync);
  • steroid medication such as prednisone and others;
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or
  • narcotic pain medication such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), oxycodone (OxyContin, Percocet), propoxyphene (Darvon, Darvocet), fentanyl (Actiq, Duragesic), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), and many others.

This list is not complete and other drugs may interact with amlodipine, hydrochlorothiazide, and olmesartan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about amlodipine, hydrochlorothiazide, and olmesartan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.02. Revision date: 12/20/2011.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.



This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use.

How this information was developed to help you make better health decisions.





© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.