Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Can a Vocal Stimulus Provoke Spontaneous Breathing in an Ischemic Stroke Patient Dependent on Mechanical Ventilation?

Condition:   Patients Ventilated by Mechanical Ventilation With Ischemic Stroke
Intervention:  
Sponsor:   The Baruch Padeh Medical Center, Poriya
Not yet recruiting - verified April 2014

ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea;   Central Sleep Apnea
Intervention:   Other: [C11]Acetate and HED PET
Sponsor:   University of Ottawa Heart Institute
Recruiting - verified April 2014

Effects of Treadmill Gait Training With Loading in Individuals With Stroke

Conditions:   Stroke;   Gait Disorders, Neurologic
Interventions:   Other: Treadmill, ankle load;   Other: Treadmill
Sponsor:   Universidade Federal do Rio Grande do Norte
Recruiting - verified April 2014

A Self-efficacy Enhancing Stroke Self-management Program for Community-dwelling Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: Stroke self-management program;   Behavioral: Usual care
Sponsor:   Queensland University of Technology
Not yet recruiting - verified April 2014

Rivaroxaban for Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Antibody Syndrome
Intervention:   Drug: Rivaroxaban
Sponsors:   St. Joseph's Healthcare Hamilton;   Heart and Stroke Foundation of Canada;   Bayer;   Hamilton Health Sciences Corporation;   Jewish General Hospital;   University of Alberta;   The Ottawa Hospital;   Queen Elizabeth II Health Sciences Centre
Not yet recruiting - verified April 2014

Effects of tDCS on Quadriceps Strength After Stroke

Condition:   Stroke
Intervention:   Device: transcranial Direct current stimulation
Sponsors:   Centre d'Investigation Clinique et Technologique 805;   FONDATION GARCHES
Not yet recruiting - verified April 2014

Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial

Conditions:   Supratentorial Neoplasms;   Brain Tumor, Primary;   Craniotomy
Intervention:   Drug: Intravenous colloid bolus with Voluven
Sponsor:   National Taiwan University Hospital
Not yet recruiting - verified April 2014

Human-Machine System for the H2 Lower Limb Exoskeleton

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Robot-assisted training with the H2 lower limb powered exoskeleton;   Behavioral: Supervised motor practice
Sponsors:   University of Houston;   The University of Texas Health Science Center, Houston;   TIRR Memorial Hermann
Recruiting - verified April 2014

Stroke - Sleep Disorders, Dysfunction of the Autonomic Nervous System and Depression

Condition:   Stroke
Intervention:  
Sponsors:   Glostrup University Hospital, Copenhagen;   Helle Klingenberg Iversen, MD, DmSc
Recruiting - verified April 2014

Stroke and Aerobic Exercise

Condition:   Stroke
Intervention:   Other: Aerobic exercise
Sponsors:   Ostergotland County Council, Sweden;   Klas Sandberg
Completed - verified April 2014

Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging

Condition:   Atherosclerosis
Intervention:   Drug: Rosuvastatin 20 mg, Aspirin 81 mg
Sponsor:   Emory University
Active, not recruiting - verified April 2014

MMP-9 Monitoring Particulate Cerebral Embolisation

Condition:   Cerebral Embolic Damage
Intervention:   Procedure: vein blood collection
Sponsor:   Peking Union Medical College Hospital
Completed - verified September 2013

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting - verified April 2014

Living Well on Androgen Deprivation Therapy

Condition:   Prostate Cancer
Interventions:   Behavioral: Exercise Sessions;   Behavioral: Nutrition Education;   Behavioral: Peer Support Volunteer
Sponsors:   British Columbia Cancer Agency;   The Prostate Centre - Vancouver Island and the Gulf Islands
Not yet recruiting - verified April 2014

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2014

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Condition:   Von Hippel-Lindau Disease
Intervention:   Drug: Vorinostat
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2014

Metabolic Costs of Walking Post Stroke

Condition:   Sub-acute Stroke
Interventions:   Other: ESTT;   Other: Traditional outpatient
Sponsor:   University of Texas Southwestern Medical Center
Recruiting - verified April 2014

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

Condition:   Diabetes Type 2
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2014

Depotentiation in People With Focal Hand Dystonia

Conditions:   Focal Dystonia;   Healthy Volunteers
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS);   Prachaya Srivanitchapoom, MD
Recruiting - verified March 2014

Emotional Communication Disorders in Cerebellar Disease

Condition:   Cerebellar Diseases
Interventions:   Behavioral: Testing of emotional communication ability;   Procedure: magnetic resonance imaging (MRI) of the brain
Sponsors:   University of Florida;   National Institute on Aging (NIA)
Not yet recruiting - verified April 2014

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified April 2014

Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke

Conditions:   Stroke;   Spasticity
Interventions:   Procedure: Tenotomy of the proximal rectus femoris tendon;   Drug: Botulinum Toxin injection in the rectus femoris muscle
Sponsor:   University Hospital of Mont-Godinne
Recruiting - verified April 2014

Use of Lokomat in Patients With Progressive Supranuclear Palsy

Condition:   Progressive Supranuclear Palsy
Interventions:   Other: MIRT and Lokomat;   Other: MIRT
Sponsor:   Ospedale Generale Di Zona Moriggia-Pelascini
Recruiting - verified April 2014

Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery

Conditions:   Cardiac Death;   Congestive Heart Failure;   Angina Pectoris;   Stroke;   Pulmonary Embolism;   Deep Vein Thrombosis
Intervention:  
Sponsor:   Technische Universität München
Recruiting - verified April 2014

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Conditions:   Coronary Disease;   Coronary Stenosis
Interventions:   Procedure: FFR guided PCI;   Procedure: CABG
Sponsors:   Stanford University;   Cardiovascular Center Aalst, Belgium;   Catharina Hospital Eindhoven;   Golden Jubilee National Hospital;   University of California, Irvine;   Medtronic;   St. Jude Medical;   Genae
Not yet recruiting - verified April 2014

Detecting and Treating High Blood Pressure in Aboriginal Population and Low and Middle Income Countries

Conditions:   Hypertension;   Cardiovascular Disease;   Diabetes
Intervention:   Other: SMS text messaging
Sponsors:   Sunnybrook Health Sciences Centre;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified April 2014

ArmeoSenso - Home Therapy and Assessment for Patients With Arm Impairments Based on Wearable Movement Sensors

Conditions:   Stroke;   Spinal Cord Injury
Intervention:   Device: ArmeoSenso
Sponsor:   University of Zurich
Recruiting - verified April 2014

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   Immunodeficiency Virus, Human
Interventions:   Drug: Aspirin 81 mg table;   Drug: Atorvastatin 40 mg
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2013

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech
Recruiting - verified April 2014

The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified April 2014

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified April 2014

Mitochondrial nt3243 A>G Mutation in Taiwan

Conditions:   MELAS Syndrome;   Noninsulin-dependent Diabetes Mellitus With Deafness
Intervention:  
Sponsors:   National Taiwan University Hospital;   National Cheng-Kung University Hospital
Recruiting - verified April 2014

Association Between Haptoglobin Genotype and Brain Swelling

Condition:   Intracerebral Hemorrhage
Intervention:   Other: Intracerebral Hemorrhage
Sponsor:   University of Florida
Recruiting - verified April 2014

Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage

Condition:   Subarachnoid Aneurysm Hemorrhage
Intervention:   Drug: Minocycline
Sponsors:   University at Buffalo;   University at Buffalo Neurosurgery
Recruiting - verified April 2014

NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery

Condition:   Aphasia
Interventions:   Device: rTMS;   Device: tDCS;   Device: Sham rTMS;   Device: Sham tDCS
Sponsors:   Thiel, Alexander, M.D.;   Dr. Alexander Thiel
Recruiting - verified April 2014

Stroke Feasibility Study

Conditions:   Atrial Fibrillation;   AFib
Intervention:   Device: AtriClip LAA Exclusion Device
Sponsor:   AtriCure, Inc.
Recruiting - verified April 2014

The Synergistic Effect of Local Anesthetics on Hemodynamic Changes During the Application of a Paravertebral Block

Conditions:   Breast Tumors;   Hypotension;   Bradycardia
Intervention:   Procedure: ultrasound guided paravertebral blocks in breast surgery
Sponsor:   University Hospital Dubrava
Active, not recruiting - verified December 2013

Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis

Conditions:   Hemiplegic Stroke;   Hemiplegic Cerebral Palsy
Intervention:   Device: Isolated Orthosis for Thumb Actuation (IOTA)
Sponsors:   Wyss Institute at Harvard University;   Children's Hospital Boston;   Deborah Munroe Noonan Memorial Research Fund
Active, not recruiting - verified April 2014

The Evaluation Of PF-04950615 (RN316) In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: PF-04950615;   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2014

The Evaluation Of PF-04950615 (RN316), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: PF-04950615;   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2014

Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis

Conditions:   Multiple Sclerosis, Primary Progressive;   Multiple Sclerosis, Secondary Progressive
Interventions:   Drug: ibudilast;   Drug: Placebo
Sponsors:   MediciNova;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Multiple Sclerosis Society
Recruiting - verified April 2014

Visual Perceptual Learning for the Treatment of Visual Field Defect

Conditions:   Stroke;   Visual Field Defect
Intervention:   Behavioral: Visual perceptual learning
Sponsor:   Asan Medical Center
Recruiting - verified April 2014

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Recruiting - verified April 2014

Study of Stroke Related Edema Treatments

Conditions:   Acute Cerebrovascular Accident;   Cerebral Edema
Interventions:   Drug: Conivaptan;   Drug: Hypertonic saline;   Drug: Mannitol
Sponsor:   University of Florida
Not yet recruiting - verified April 2014

Automated Versus Manual Fluid Management for High Risk Abdominal Surgical Patient. A Prospective, Randomized Trial

Conditions:   Major Abdominal Surgery;   Colorectal Surgery;   Hepatectomy;   Pancreatectomy;   Pancreaticoduodenectomy
Interventions:   Device: Closed loop automated System (LIR®: learning intravenous resuscitator);   Device: manual current practice by anesthesiologist team
Sponsors:   Hospices Civils de Lyon;   University of California, Irvine
Recruiting - verified April 2014

Blood Pressure Variability in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Intervention:  
Sponsors:   Aristotle University Of Thessaloniki;   A&D Company Limited
Recruiting - verified December 2013

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: None - this is an observational study
Sponsors:   University of Virginia;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2014

Cortical Recording and Stimulating Array Brain-Machine Interface

Conditions:   Tetraplegia;   Spinal Cord Injury;   Brainstem Stroke
Intervention:   Device: Implantation of CRS Arrays in the motor cortex and sensory cortex of the brain
Sponsors:   University of Pittsburgh;   Defense Advanced Research Projects Agency;   Department of Defense;   Johns Hopkins University
Recruiting - verified April 2014

Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels

Conditions:   Spinal Cord Injury;   Tetraplegia;   Quadraplegia;   Low HDL-c;   High LDL-c
Intervention:   Dietary Supplement: Omega-3 supplements
Sponsors:   University of Manitoba;   The Association of Rehabilitation Medicine in Manitoba
Recruiting - verified April 2014

A Study of Alegitazar in Patients With Type 2 Diabetes And Chronic Kidney Disease (Alerenal Study)

Condition:   Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Withdrawn - verified April 2014

Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: MAHI EXO-II exoskeleton augmented with BMI system
Sponsors:   The University of Texas Health Science Center, Houston;   University of Houston;   The Methodist Hospital System;   National Institute of Neurological Disorders and Stroke (NINDS);   TIRR Memorial Hermann
Recruiting - verified April 2014

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following Hospitalization for Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2014

Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage

Condition:   Subarachnoid Hemorrhage, Aneurysmal
Intervention:   Drug: Etanercept
Sponsor:   St. Michael's Hospital, Toronto
Not yet recruiting - verified April 2014

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

Clinical and Neuropsychological Investigations in Batten Disease

Condition:   Neuronal Ceroid Lipofuscinosis
Intervention:  
Sponsors:   University of Rochester;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2014

Study of Thyroid Hormones in Prematures

Condition:   Transient Hypothyroxinemia of Prematurity (THOP)
Interventions:   Drug: thryoid hormone T4 + oral potassium iodide (KI) for 42 days;   Drug: D5W - 5% dextrose water
Sponsors:   New York Medical College;   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified April 2014

Discharge Educational Strategies for Reduction of Vascular Events

Conditions:   Intracerebral Infarcts;   Ischemic Stroke;   Hemorrhagic Strokes;   TIA's
Intervention:   Behavioral: DESERVE education
Sponsors:   New York University School of Medicine;   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery

Conditions:   High Risk Non-cardiac Surgery;   Death;   Delirium;   Kidney Injury;   Myocardial Infarction;   Respiratory Failure;   Postoperative Infection
Intervention:   Other: Observational study
Sponsors:   University of Manitoba;   Canadian Anesthesia Research Foundation;   University of Manitoba Department of Anesthesia
Not yet recruiting - verified April 2014

The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome

Conditions:   Antiphospholipid Syndrome;   Endothelial Dysfunction;   Hyperuricemia;   Gout;   Metabolic Syndrome
Intervention:  
Sponsor:   National Taiwan University Hospital
Recruiting - verified April 2014

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer Pharma AG
Recruiting - verified April 2014

Sleep to Lower Elevated Blood Pressure

Conditions:   Hypertension;   Sleep Disorders;   Insomnia;   Cardiovascular Diseases
Intervention:   Behavioral: Online Sleep Education
Sponsors:   University College Hospital Galway;   Health Research Board, Ireland
Active, not recruiting - verified April 2014

MicroRNA Diagnostics in Subarachnoid Hemorrhage

Condition:   Subarachnoid Hemorrhage
Intervention:  
Sponsors:   Rigshospitalet, Denmark;   Bispebjerg Hospital
Completed - verified April 2014

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified April 2014

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure.

Conditions:   Modified Release Oral Formulation;   Left Ventricular Systolic Dysfunction;   Chronic Heart Failure;   History of Chronic Heart Failure;   Left Ventricular Ejection Fraction;   Pharmacokinetics;   Echocardiogram
Interventions:   Drug: Omecamtiv mecarbil;   Drug: Omecamtiv mecarbil;   Drug: Placebo;   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil
Sponsors:   Amgen;   Cytokinetics
Recruiting - verified April 2014

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Device: Evolocumab (AMG 145);   Device: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Recruiting - verified April 2014

Safety and Efficacy of Desensitization Therapy in Sensitized Participants Awaiting Heart Transplantation

Conditions:   Transplantation;   Organ Transplantation;   Heart Transplantation
Interventions:   Drug: Bortezomib;   Procedure: Plasmapheresis on days 0, 1 and 2.
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Clinical Trials in Organ Transplantation (CTOT)
Recruiting - verified April 2014

Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)

Conditions:   Infections;   Human Cathelicidin Antimicrobial Peptide (hCAP-18)
Interventions:   Dietary Supplement: vitamin D3;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: fish oil placebo
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified April 2014

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Asia

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities

Condition:   Cardiovascular Disease, Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

LungVITamin D and OmegA-3 Trial (lungVITAL)

Conditions:   COPD;   Asthma;   Pulmonary Function;   Pneumonia
Interventions:   Dietary Supplement: Vitamin D;   Dietary Supplement: fish oil;   Dietary Supplement: Vitamin D placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Brigham and Women's Hospital;   Harvard School of Public Health
Active, not recruiting - verified April 2014

A Study to Assess Cardiovascular Outcomes Following Treatment With MK-3102 in Participants With Type 2 Diabetes Mellitus (MK-3102-018)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: MK-3102;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Recruiting - verified April 2014

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL

Conditions:   Depression;   Depressive Symptoms;   Mood
Interventions:   Dietary Supplement: vitamin D3;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Fish oil placebo;   Dietary Supplement: Vitamin D placebo
Sponsors:   Brigham and Women's Hospital;   National Institute of Mental Health (NIMH)
Active, not recruiting - verified April 2014

Vitamin D and Omega-3 Trial to Prevent and Treat Diabetic Kidney Disease

Condition:   Diabetes
Interventions:   Dietary Supplement: Vitamin D;   Drug: Omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   University of Washington;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified April 2014

Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke

Condition:   Stroke
Interventions:   Device: Vivistim System;   Other: Rehab Only
Sponsor:   MicroTransponder Inc.
Recruiting - verified April 2014

Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke

Conditions:   Hemiparesis;   Stroke
Interventions:   Behavioral: Visual feedback therapy #1;   Behavioral: Visual feedback therapy #2
Sponsor:   Albert Einstein Healthcare Network
Enrolling by invitation - verified April 2014

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2014

Rehabilitation Combined With Bihemispherictranscranial Direct Current Stimulation in Subacute Ischemic Stroke

Conditions:   First Ever Clinical Stroke;   Ischemic Stroke;   Subacute Phase;   Persistent Hemiparesis of Upper Extremity
Interventions:   Procedure: transcranial direct current stimulation (tDCS);   Procedure: Sham stimulation, then tDCS;   Procedure: Sham stimulation
Sponsors:   Ospedale Civico, Lugano;   Dr. med. Carlo Cereda;   University Hospital Inselspital, Berne;   Helios Klinik Zihlschlacht;   Clinica Hildebrand Brissago;   Advisory Board Research Ente Ospedaliero Cantonale
Recruiting - verified April 2014

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

Conditions:   Carotid Stenosis;   Atherosclerosis;   Stroke;   Transient-ischaemic Attack;   TIA;   Amaurosis Fugax
Interventions:   Drug: Revacept;   Drug: Placebo
Sponsor:   AdvanceCor GmbH
Recruiting - verified April 2014

Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process

Condition:   Chronic Fatigue Syndrome
Interventions:   Behavioral: Patient-Partner Videotelephone-delivered Health Information (PP-T-HI);   Behavioral: Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Improving Anticoagulation Control in VISN 1

Conditions:   Anticoagulants;   Atrial Fibrillation;   Venous Thromboembolism
Intervention:   Behavioral: Outreach, Education, and Motivational Interviewing
Sponsor:   Department of Veterans Affairs
Not yet recruiting - verified April 2014

Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes

Condition:   Type 2 Diabetes
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 fatty acid (fish oil);   Dietary Supplement: Vitamin D3 placebo;   Drug: Fish oil placebo
Sponsors:   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified April 2014

Impact of Vitamin D Supplementation on Cardiac Structure and Function

Condition:   Cardiovascular Disease
Interventions:   Dietary Supplement: Vitamin D3 + fish oil/fish oil placebo;   Dietary Supplement: Vitamin D3 placebo + fish oil/fish oil placebo
Sponsors:   Massachusetts General Hospital;   Brigham and Women's Hospital
Active, not recruiting - verified April 2014

The HEP-OKS Study - Hemifield Eye Patching and Optokinetic Stimulation to Treat Hemispatial Neglect in Stroke Patients

Conditions:   Spatial Neglect;   Cerebral Stroke
Intervention:   Behavioral: hemifield eye patching (HEP) + optokinetic stimulation (OKS)
Sponsors:   University of Luebeck;   German Research Foundation
Completed - verified April 2014

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified April 2014

The 36-month Extension to Follow up Sub Study

Conditions:   Postphlebitic Syndrome;   Post-Thrombotic Syndrome;   Deep Vein Thrombosis
Intervention:  
Sponsors:   Sir Mortimer B. Davis - Jewish General Hospital;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Canada;   Sigvaris Corporation
Active, not recruiting - verified April 2014

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2014

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2014

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy

Condition:   Internal Carotid Artery Stenosis
Interventions:   Procedure: sonolysis;   Procedure: endarterectomy;   Procedure: carotid stenting
Sponsors:   University Hospital Ostrava;   Palacky University
Recruiting - verified April 2014

Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation

Condition:   Stroke
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham stimulation
Sponsors:   Emory University;   Cathrin Buetefisch;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2014

Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision

Condition:   Stroke
Intervention:  
Sponsors:   Emory University;   Cathrin Buetefisch;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells

Condition:   Traumatic Brain Injury
Intervention:   Biological: autologous bone marrow mononuclear cells
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting - verified April 2014

Characterization of Cardiac Hemodynamics During MultiSite Pacing

Condition:   Heart Failure
Intervention:  
Sponsor:   St. Jude Medical
Completed - verified April 2014

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy

Condition:   Cardiomegaly
Intervention:   Drug: MEK162
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Interests of Strengthening Isokinetic Upper Extremity Hemiparetic Sequelae in Patients

Condition:   Partial Deficiency of Muscle Strength
Interventions:   Other: isokinetic strength training;   Other: passive motion
Sponsor:   University Hospital, Montpellier
Recruiting - verified April 2014

Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: bicalutamide;   Drug: buserelin;   Drug: flutamide;   Drug: goserelin acetate;   Drug: leuprolide acetate;   Drug: orteronel;   Drug: triptorelin
Sponsors:   Radiation Therapy Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Effects of rTMS and tDCS on Motor Function in Stroke

Conditions:   Stroke;   Motor Function
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Transcranial Direct Current Stimulation (tDCS)
Sponsor:   Spaulding Rehabilitation Hospital
Active, not recruiting - verified April 2014

New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome

Conditions:   Obstructive Sleep Apnoea Hypopnoea Syndrome;   Biomarkers of Fibrin Clot Structure;   Biomarkers of Vascular Endothelial Injury
Intervention:  
Sponsors:   Hywel Dda Health Board;   National Institute for Health Research, United Kingdom;   Abertawe Bro Morgannwg University NHS Trust;   Swansea University
Completed - verified April 2014

Phenylephrine Versus Norepinephrine in Ophthalmic Surgery

Condition:   Bloodpressure
Interventions:   Drug: phenylephrine;   Drug: norepinephrine
Sponsor:   University Medical Centre Groningen
Completed - verified April 2014

Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics.

Condition:   Hypercholesterolemia
Intervention:   Dietary Supplement: beetroot juice
Sponsors:   Queen Mary University of London;   British Heart Foundation
Completed - verified April 2014

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified April 2014

Iloprost Therapy in Patients With Critical Limb Ischemia

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Iloprost (Ilomedin, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

Cardiovascular and Torsades de Pointes Monitoring for Pazopanib

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: Pazopanib;   Drug: Other anti-VEGFs
Sponsor:   GlaxoSmithKline
Active, not recruiting - verified April 2014

Risk Factors for Coronary Artery Calcification and Left Ventricular Hypertrophy in Hemodialysis Patients

Condition:   End Stage Renal Disease
Intervention:  
Sponsors:   University of Alberta;   Massachusetts General Hospital
Recruiting - verified April 2014

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsors:   National Institutes of Health Clinical Center (CC);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2014

Adolescent Master Protocol

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   Office of AIDS Research
Active, not recruiting - verified April 2014

Evaluation of the Genu Neurexa Orthosis in Post Stroke Patients

Condition:   Stroke
Intervention:   Device: Genu Neurexa orthosis
Sponsors:   Hadassah Medical Organization;   Otto Bock Healthcare Products GmbH
Terminated - verified October 2012

PRISM Registry: Pseudobulbar Affect Registry Series

Conditions:   Alzheimer's Disease;   Amyotrophic Lateral Sclerosis (ALS);   Multiple Sclerosis (MS);   Parkinson's Disease;   Stroke;   Traumatic Brain Injury
Intervention:  
Sponsor:   Avanir Pharmaceuticals
Completed - verified April 2014

Gait Parameters Analysis in Post-stroke Patients and in Elderly Fallers

Conditions:   Healthy;   Thalamic Pain Syndrome;   Fallers
Intervention:   Other: Gait analysis
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified April 2014

Observational Study on Determinants of Dementia After Stroke

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke
Intervention:  
Sponsor:   Ludwig-Maximilians - University of Munich
Recruiting - verified April 2014

A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition:   Cardiovascular Disease, Rheumatoid Arthritis
Interventions:   Drug: tocilizumab [RoActemra/Actemra];   Drug: etanercept
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified April 2014

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves

Condition:   Symptomatic Severe Aortic Stenosis
Interventions:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2014

Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

Condition:   Antiretroviral Toxicity
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   Office of AIDS Research
Recruiting - verified April 2014

A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Biological: Allogeneic adult mesenchymal bone marrow stem cells
Sponsors:   Stemedica Cell Technologies, Inc.;   University of California, San Diego;   Mercy Gilbert Medical Center at AZ;   Chandler Regional Medical Center at Chandler AZ
Recruiting - verified April 2014

Carotid Plaque Imaging in Acute Stroke

Conditions:   Stroke;   Ischemic Attack, Transient
Intervention:  
Sponsors:   Ludwig-Maximilians - University of Munich;   Technische Universität München
Recruiting - verified April 2014

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

Effect of Goal- Directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity

Condition:   Postoperative Complications
Interventions:   Other: Crystalloid;   Other: Colloid
Sponsor:   The Cleveland Clinic
Recruiting - verified April 2014

Pilot Investigation of Stem Cells in Stroke

Condition:   Stroke
Intervention:   Biological: CTX0E03 neural stem cells
Sponsor:   ReNeuron Limited
Active, not recruiting - verified April 2014

Anticoagulation in Stent Intervention

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Acetylsalicylic Acid + clopidogrel + acenocoumarol;   Drug: Acetylsalicylic Acid + clopidogrel
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified April 2014

The Neurotrophic Effects of Lithium Carbonate Following Stroke: A Feasibility Study

Condition:   Stroke
Intervention:   Drug: Lithium Carbonate
Sponsor:   Sunnybrook Health Sciences Centre
Recruiting - verified April 2014

Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure

Condition:   Heart Failure
Interventions:   Drug: Eplerenone;   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2014

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

Condition:   Stroke
Intervention:   Device: Transcranial Stimulation
Sponsor:   Spaulding Rehabilitation Hospital
Active, not recruiting - verified April 2014

Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain

Condition:   Shoulder Pain
Intervention:   Device: The SPR System
Sponsor:   NDI Medical, LLC
Recruiting - verified April 2014

Management Practices and the Risk of Infection Following Cardiac Surgery

Conditions:   Cardiac Surgery;   Infection, Postoperative Wound;   Postoperative Wound Infection;   Infections, Nosocomial;   Management Practices
Intervention:  
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2014

Vitamin D and Omega-3 Trial (VITAL)

Conditions:   Cancer;   Cardiovascular Disease
Interventions:   Dietary Supplement: vitamin D3;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Brigham and Women's Hospital;   National Cancer Institute (NCI);   National Heart, Lung, and Blood Institute (NHLBI);   Office of Dietary Supplements (ODS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Complementary and Alternative Medicine (NCCAM)
Active, not recruiting - verified April 2014

Action in Diabetes and Vascular Disease Preterax and Diamicron MR Controlled Evaluation Post Trial Observational Study

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   The George Institute;   Servier
Completed - verified April 2014

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Procedure: Metabolic Chamber
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2014

Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair;   Procedure: CABG
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2014

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair with Annuloplasty;   Procedure: Mitral Valve Replacement
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2014

Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study)

Conditions:   Arterial Thromboembolic Events;   Atrial Fibrillation
Interventions:   Drug: Placebo;   Drug: Dalteparin
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2014

Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation

Conditions:   Stroke;   Atrial Fibrillation;   Embolism
Interventions:   Drug: warfarin tablets;   Drug: Edoxaban tablets (high dose regimen);   Drug: Edoxaban tablets (low dose regimen)
Sponsors:   Daiichi Sankyo Inc.;   The TIMI Study Group
Completed - verified April 2014

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta)
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified April 2014

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Antiepileptic Drugs and Vascular Risk Markers

Condition:   Subarachnoid Hemorrhage
Interventions:   Drug: phenytoin;   Drug: valproate;   Drug: levetiracetam
Sponsor:   Thomas Jefferson University
Terminated - verified April 2014

PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF)

Condition:   Atrial Fibrillation
Interventions:   Procedure: PV-Isolation RF;   Procedure: PV-Isolation Cryo
Sponsors:   Staedtisches Klinikum Karlsruhe;   Heidelberg University
Active, not recruiting - verified April 2014

Exercise and Inflammation in the Elderly

Conditions:   Inflammation;   Insulin Sensitivity
Interventions:   Other: Weight Loss;   Other: Aerobic Exercise Training
Sponsors:   Department of Veterans Affairs;   University of Maryland;   Johns Hopkins University
Active, not recruiting - verified April 2014

Tranexamic Acid in Urologic Surgery

Conditions:   Bleeding;   Prostatectomy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Università Vita-Salute San Raffaele
Completed - verified July 2010

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:  
Sponsor:   Duke University
Recruiting - verified February 2014

Evaluating the Relationship Between Fatty Acids and Heart Disease

Conditions:   Cardiovascular Diseases;   Heart Failure, Congestive;   Atrial Fibrillation;   Cerebrovascular Accident
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   Office of Dietary Supplements (ODS)
Completed - verified April 2014

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified April 2013

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2014

3-D Transcranial Ultrasound Analysis Study

Conditions:   Cerebrovascular Accident;   Intracranial Hypertension
Interventions:   Device: 3-D ultrasound scanner;   Drug: Perflutren Protein-Type A Microspheres for injection
Sponsor:   Duke University
Completed - verified April 2014

Intravenous Administration of Microplasmin for Treatment of Acute Ischemic Stroke

Condition:   Stroke, Acute
Interventions:   Drug: Microplasmin;   Drug: Microplasmin
Sponsor:   ThromboGenics
Completed - verified April 2014

Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion

Condition:   Stroke
Intervention:   Drug: Microplasmin
Sponsor:   ThromboGenics
Terminated - verified April 2014

Measuring Levels of SMN in Blood Samples of SMA Patients

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2014

Nurses' Health Study (Cardiovascular Component)

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Coronary Disease;   Heart Diseases;   Cerebrovascular Accident;   Pulmonary Embolism;   Angina Pectoris;   Myocardial Infarction;   Menopause;   Postmenopause
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF)

Conditions:   Arrhythmia;   Atrial Fibrillation;   Cardiovascular Diseases;   Cerebral Embolism and Thrombosis;   Cerebrovascular Disorders;   Heart Diseases;   Thrombophlebitis;   Cerebrovascular Accident
Intervention:   Drug: warfarin
Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

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