High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Amiloride for Resistant Hypertension

Conditions:   Hypertension;   Type 2 Diabetes Mellitus;   Microalbuminuria
Intervention:   Drug: Amiloride
Sponsors:   Odense University Hospital;   Ib Abildgaard Jacobsen
Completed - verified April 2014

Carvedilol PAH A Pilot Study of Efficacy and Safety

Conditions:   Pulmonary Hypertension;   Cardiac MRI <40
Intervention:   Drug: Carvedilol
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting - verified April 2014

Comparative Effectiveness of Ambulatory Blood Pressure Monitoring vs Usual Care for Diagnosing and Managing Hypertension: A Pilot Study

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Chlorthalidone;   Drug: Losartan
Sponsors:   University of North Carolina, Chapel Hill;   Anthony J Viera, MD, MPH;   North Carolina Translational and Clinical Sciences Institute
Not yet recruiting - verified April 2014

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Not yet recruiting - verified April 2014

Effect of Mat Pilates Training on Blood Pressure of Hypertensive Individuals

Condition:   Hypertension
Intervention:   Behavioral: Mat Pilates Training
Sponsors:   Federal University of São Paulo;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Completed - verified April 2014

Renal Denervation in Patients With Heart Failure With Normal LV Ejection Fraction

Conditions:   Heart Failure, Diastolic;   Hypertension
Intervention:   Procedure: Renal denervation + medical therapy
Sponsor:   InCor Heart Institute
Recruiting - verified April 2014

Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.

Condition:   Mechanical Ventilation Complication
Interventions:   Drug: Fentanyl;   Procedure: Sedation assessment;   Procedure: Screen of weaning;   Drug: Propofol;   Drug: Midazolam;   Drug: Dexmedetomidine
Sponsors:   Tianjin Third Central Hospital;   Chinese Medical Association
Not yet recruiting - verified April 2014

Endothelin Receptor Function and Acute Stress

Condition:   Hypertension
Interventions:   Drug: Bosentan;   Drug: Placebo
Sponsors:   Georgia Regents University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified April 2014

Triptolide-Containing Formulation as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Condition:   Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions:   Drug: Triptolide-Containing Formulation;   Drug: Placebo
Sponsor:   Shanghai Changzheng Hospital
Recruiting - verified April 2014

Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation, Renal Artery Denervation or Both.

Conditions:   Paroxysmal Atrial Fibrillation;   Persistent Atrial Fibrillation;   Hypertension
Intervention:   Procedure: procedure
Sponsor:   Diagram B.V.
Recruiting - verified April 2014

Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH

Conditions:   Pulmonary Arterial Hypertension;   PAH
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Not yet recruiting - verified April 2014

Carnitine for the Treatment of Atherosclerosis.

Condition:   Metabolic Syndrome
Interventions:   Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Lactose capsules
Sponsors:   Queen's University;   Heart and Stroke Foundation of Canada
Not yet recruiting - verified April 2014

Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease

Condition:   Focus Chronic Kidney Disease With Hypertension
Intervention:   Behavioral: Exercise
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2014

Effects of Somatostatin on ADPKD Heart

Conditions:   Autosomal Dominant Polycystic Kidney Disease;   Glomerular Filtration Rate > 40 ml/Min
Interventions:   Drug: Octeotride;   Drug: Placebo
Sponsor:   Federico II University
Completed - verified January 2014

Von Willebrand Factor to Predict Postoperative Outcome

Conditions:   Liver Dysfunction;   Morbidity;   Mortality;   Hospitalisation
Intervention:  
Sponsor:   Medical University of Vienna
Not yet recruiting - verified April 2014

Study of a Community Based Approach to Control Cardiovascular Risk Factors in India

Conditions:   Hypertension;   Diabetes;   Smoking;   Cardiovascular Diseases
Intervention:   Behavioral: Community health worker
Sponsor:   University Hospitals of Cleveland
Recruiting - verified April 2014

Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma

Condition:   Congenital Glaucoma
Interventions:   Device: Ologen Collagen Matrix;   Procedure: Combined trabeculotomy-trabeculectomy
Sponsors:   National Centre of Ophthalmology named after academician Zarifa Aliyeva;   Aeon Astron Europe B.V.
Active, not recruiting - verified April 2014

Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:  
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2014

Frequency and Clinical Significance of Renal and Bone Toxicity in HIV-infected Patients

Condition:   Renal Toxicity
Intervention:  
Sponsor:   Asociacion para el Estudio de las Enfermedades Infecciosas
Recruiting - verified April 2014

Hemodynamic Effects of Terlipressin and High Dose Octreotide

Condition:   Gastric and Esophageal Varices
Interventions:   Drug: Terlipressin;   Drug: Octreotide
Sponsor:   Shanghai Zhongshan Hospital
Recruiting - verified April 2014

Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

Condition:   Scheduled Laparoscopic Surgery
Interventions:   Device: Pupillometry guided analgesia (PP);   Drug: Tailored remifentanil controlled infusion;   Drug: Tailored antihypertensive drug administration
Sponsor:   Central Hospital, Nancy, France
Recruiting - verified April 2014

Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure

Condition:   Glaucoma, Open Angle
Interventions:   Drug: Cyclosporine;   Drug: Betamethasone
Sponsor:   Mashhad University of Medical Sciences
Recruiting - verified April 2014

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Not yet recruiting - verified April 2014

A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323

Condition:   Hypertension
Interventions:   Drug: GSK587323;   Drug: FDC of candesartan cilexetil 16 mg and HCTZ 12.5mg
Sponsor:   GlaxoSmithKline
Not yet recruiting - verified March 2014

Gastric Varices Treatment: Coil + Cyanoacrylate Versus Cyanoacrylate

Condition:   Gastric Varices
Interventions:   Device: Treatment: coil + cyanoacrylate;   Device: Treatment: cyanoacrylate
Sponsor:   University of Sao Paulo General Hospital
Recruiting - verified August 2012

Outcomes of Angiotensin Converting Enzyme Inhibitor Management Strategies Prior to Coronary Artery Bypass

Condition:   Coronary Artery Disease
Interventions:   Drug: ACE/ARB continuation;   Drug: ACE/ARB withdrawal
Sponsor:   University of Alberta
Recruiting - verified April 2014

A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)

Conditions:   Ocular Hypertension;   Open Angle-glaucoma
Interventions:   Drug: ONO-9054;   Drug: Latanoprost
Sponsor:   Ono Pharmaceutical Co. Ltd
Not yet recruiting - verified March 2014

Azilsaltan Tablets (Azilva Tablets) Special Drug Use Surveillance "Hypertension Complicated by Diabetes "

Condition:   Hypertension
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Recruiting - verified April 2014

A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2014

A Multiple Dose Titration Study of MK-8892 in Participants With Pulmonary Hypertension and Left Heart Disease (MK-8892-007)

Conditions:   Pulmonary Hypertension;   Left Heart Disease
Intervention:   Drug: MK-8892
Sponsor:   Merck Sharp & Dohme Corp.
Not yet recruiting - verified April 2014

Relative Bioavailability Study of One Amlodipine 10mg Tablet and One Rosuvastatin 20mg Tablet to Two Fixed Dose Combinations of Amlodipine (10mg) and Rosuvastatin (20mg) in Healthy Subjects Under Fasting Conditions

Condition:   Hypertension
Interventions:   Drug: Amlodipine+Rosuvastatin;   Drug: GSK3074477 FDC - 1;   Drug: GSK3074477 FDC - 2
Sponsors:   GlaxoSmithKline;   SingHealth Investigational Medicine Unit, Singapore
Not yet recruiting - verified April 2014

Azilsartan Tablets Special Drug Use Surveillance: Long-term Use

Condition:   Hypertension
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Active, not recruiting - verified April 2014

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

Condition:   Severe Pre-eclampsia, Postpartum Condition or Complication
Interventions:   Drug: misoprostol;   Drug: carbetocin
Sponsors:   Benha University;   khalid abd aziz mohamed
Recruiting - verified April 2014

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: sildenafil citrate;   Drug: sildenafil citrate;   Drug: sildenafil citrate
Sponsor:   Pfizer
Not yet recruiting - verified April 2014

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Not yet recruiting - verified April 2014

CKD-346 DDI Study(Telmisartan/S-Amlodipine, Rosuvastatin)

Conditions:   Hypertension;   Hyperlipidemia
Interventions:   Drug: Telmisartan/S-Amlodipine;   Drug: Rosuvastatin;   Drug: Telmisartan/S-Amlodipine + Rosuvastatin;   Drug: Telmisartan/S-Amlodipine + Rosuvastatin
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified April 2014

Novel Drug Delivery Technique Via Retroject Device

Condition:   Glaucoma
Interventions:   Device: Retroject Device only;   Device: Retroject device with ethacrynic acid injection;   Other: ethacrynic acid or balanced salt solution
Sponsors:   Duke University;   Molly Walsh
Not yet recruiting - verified April 2014

Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: lloprost(Ventavis,BAYQ6252, 20 µg/mL);   Drug: lloprost(Ventavis,BAYQ6252, 10 µg/mL)
Sponsor:   Bayer
Recruiting - verified April 2014

iDropper Usability in Glaucoma

Condition:   Glaucoma, Open-Angle [C11.525.381.407]
Intervention:   Device: Open angle glaucoma - iDropper device
Sponsors:   Care Team Solutions;   National Eye Institute (NEI)
Recruiting - verified April 2014

Safety and Efficacy Study for Treatment of Anemia in Newly Initiated Dialysis Patients

Condition:   Anemia of End-stage Renal Disease
Interventions:   Drug: FG-4592;   Drug: Epoetin Alfa
Sponsors:   FibroGen;   Astellas Pharma Europe B.V.;   AstraZeneca
Recruiting - verified April 2014

MERIT-1: Macitentan in thE tReatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Interventions:   Drug: Macitentan;   Drug: Placebo
Sponsor:   Actelion
Recruiting - verified April 2014

Comparison of Latanoprost PPDS With Timolol Maleate GFS in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Conditions:   Ocular Hypertension;   Open-Angle Glaucoma
Interventions:   Drug: Latanoprost Punctal Plug Delivery System (L-PPDS);   Drug: Timolol Maleate GFS, 0.5%
Sponsor:   Mati Therapeutics Inc.
Recruiting - verified April 2014

Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2014

Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsors:   James J. Peters Veterans Affairs Medical Center;   Kessler Foundation
Recruiting - verified April 2014

Add-on to Micamlo BP Trial

Condition:   Hypertension
Interventions:   Drug: Telmisartan + amlodipine;   Drug: hydrochlorothiazide;   Drug: Telmisartan + amlodipine;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Take Charge of Your Diabetes

Conditions:   Diabetes;   Hypertension
Intervention:   Behavioral: Financial Incentive: Fixed Lottery
Sponsors:   University of Pennsylvania;   National Institute on Aging (NIA)
Active, not recruiting - verified April 2014

Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Canagliflozin;   Drug: Placebo
Sponsor:   Janssen Scientific Affairs, LLC
Recruiting - verified April 2014

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

Conditions:   Heart Disease;   Heart Failure With Preserved Ejection Fraction;   Exercise Intolerance;   Pulmonary Hypertension
Interventions:   Drug: Nitrite;   Drug: Saline Placebo for Nitrite
Sponsors:   Mayo Clinic;   Barry Borlaug
Recruiting - verified April 2014

Sleep Apnea in Type 1 Diabetes

Condition:   Type 1 Diabetes, Sleep Apnea Syndrome
Interventions:   Other: Polysomnography;   Other: Evaluation of the autonomous nervous system;   Other: Clinical examination of the sleep;   Other: Clinical examination of diabetology;   Other: Biological dosages;   Other: Electrocardiogram (ECG);   Other: Carotid echography;   Other: Blood pressure
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Recruiting - verified April 2014

Improving Hypertension Control

Condition:   Hypertension
Intervention:   Behavioral: Lifestyle counseling
Sponsors:   Medical College of Wisconsin;   Progressive Community Health Center
Recruiting - verified April 2014

Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Mitomycin C and Provisc in Steroid Induced Glaucoma

Condition:   Steroid Induced Glaucoma
Interventions:   Device: Ologen Collagen Matrix;   Drug: Mitomycin C (MMC) and Provisc
Sponsors:   National Centre of Ophthalmology named after academician Zarifa Aliyeva;   Aeon Astron Europe B.V.
Recruiting - verified April 2014

Relaxin in Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis, Relapsing-Remitting
Interventions:   Procedure: Blood Draw;   Procedure: Lumbar Puncture
Sponsors:   Providence Health & Services;   Providence Brain & Spine Institute
Recruiting - verified April 2014

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified April 2014

Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension
Intervention:   Drug: Ambrisentan 5 mg
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2014

Peri-operative Cefazolin Prophylaxis at Time of Cesarean Delivery in the Obese Gravida

Conditions:   Obesity;   Pregnancy
Intervention:   Drug: Pre-operative cefazolin
Sponsor:   University of Pittsburgh
Active, not recruiting - verified April 2014

Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension.

Condition:   Hypertension
Interventions:   Drug: Ambrisentan 5 mg;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2014

Registry to Evaluate the ROX COUPLER in Patients With Resistant or Uncontrolled Hypertension

Conditions:   Hypertension;   Blood Pressure, High;   Blood Pressure, Resistant;   Blood Pressure, Uncontrolled
Intervention:   Device: ROX COUPLER
Sponsor:   ROX Medical, Inc.
Recruiting - verified April 2014

Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan

Condition:   Hypertension
Interventions:   Drug: LCZ696;   Drug: Olmesartan;   Drug: Placebo of LCZ696;   Drug: Placebo of Olmesartan
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria

Condition:   Type 2 Diabetes Mellitus With Diabetic Nephropathy
Interventions:   Drug: GKT137831;   Drug: Placebo
Sponsor:   Genkyotex Innovation SAS
Recruiting - verified April 2014

A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension

Condition:   Hypertension
Interventions:   Drug: LCZ696;   Drug: olmesartan;   Other: placebo to LCZ696;   Other: placebo to olmesartan
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy

Condition:   Prostate Cancer
Interventions:   Drug: Abiraterone Acetate;   Drug: Prednisone 5 mg twice daily;   Drug: Prednisone 5 mg once daily;   Drug: Prednisone 2.5 mg twice daily;   Drug: Dexamethasone 0.5 mg once daily
Sponsor:   Janssen Pharmaceutica N.V., Belgium
Recruiting - verified April 2014

Flow MRI in Normal Pressure Hydrocephalus

Condition:   Normal Pressure Hydrocephalus
Intervention:   Other: Flow imaging
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2014

AC-055-402: An Extension of AC-055-401, Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Completed - verified April 2014

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified April 2014

SYMPHONY: A Study of Macitentan in Pulmonary Arterial Hypertension to Validate the PAH-SYMPACT

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2014

Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer

Condition:   Pancreatic Cancer
Interventions:   Drug: FOLFIRINOX;   Drug: Losartan;   Radiation: Proton Beam Radiation
Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Sleep to Lower Elevated Blood Pressure

Conditions:   Hypertension;   Sleep Disorders;   Insomnia;   Cardiovascular Diseases
Intervention:   Behavioral: Online Sleep Education
Sponsors:   University College Hospital Galway;   Health Research Board, Ireland
Recruiting - verified April 2014

Efficacy Study of Ambrisentan in Chinese Patients With Pulmonary Arterial Hypertension (PAH)

Condition:   Vascular Disease
Intervention:   Drug: ambrisentan
Sponsor:   GlaxoSmithKline
Recruiting - verified March 2014

An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Creation of an Arteriovenous Fistula to Facilitate Hemodialysis Access

Condition:   Arteriovenous Fistula
Interventions:   Biological: SRM003;   Other: Participating Site's standard practice
Sponsor:   Shire
Active, not recruiting - verified April 2014

An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Placement of an Arteriovenous Graft to Facilitate Hemodialysis Access

Condition:   Arteriovenous Graft
Interventions:   Biological: SRM003;   Other: Participating Site's standard practice
Sponsor:   Shire
Active, not recruiting - verified April 2014

Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness

Condition:   Chronic Multisymptom Illness in Gulf War Veterans
Intervention:   Device: Intranasal Insulin
Sponsors:   Bronx Veterans Medical Research Foundation, Inc;   VA Boston Healthcare System;   Boston University
Recruiting - verified April 2014

Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Available - verified April 2014

Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension Patients

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

A Non-Interventional Follow Up Study For Subjects Who Received Sildenafil for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Condition:   Pulmonary Hypertension, Persistent, of the Newborn
Intervention:   Other: non-interventional
Sponsor:   Pfizer
Completed - verified April 2014

Measurement of Autonomic Cardiovascular Integrity in Persons With SCI

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Recruiting - verified April 2014

Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma

Condition:   Hemangioma
Interventions:   Drug: Acebutolol;   Drug: Propanolol
Sponsor:   University Hospital, Montpellier
Recruiting - verified April 2014

MAESTRO (Macitentan in Eisenmenger Syndrome To Restore Exercise Capacity)

Condition:   Eisenmenger Syndrome
Interventions:   Drug: Macitentan 10 mg, oral tablet, to be taken once daily.;   Drug: Matching placebo oral tablet, to be taken once daily.
Sponsor:   Actelion
Recruiting - verified April 2014

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2014

The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study

Condition:   End- Stage Renal Disease Patients
Intervention:   Procedure: hemodialysis
Sponsor:   National Taiwan University Hospital
Withdrawn - verified April 2014

A Multicenter Study to Evaluate the ROX Arteriovenous Coupler in Patients With Treatment-Resistant Hypertension

Condition:   Hypertension
Intervention:   Device: ROX COUPLER
Sponsor:   ROX Medical, Inc.
Recruiting - verified April 2014

Renal Denervation by MDT-2211 System in Patients With Uncontrolled Hypertension

Condition:   Uncontrolled Hypertension
Intervention:   Device: MDT-2211 Renal Denervation System
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2014

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2014

Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura

Condition:   Purpura, Schoenlein-Henoch
Intervention:  
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified July 2012

Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis
Interventions:   Drug: RE-021 (Sparsentan);   Drug: Irbesartan
Sponsor:   Retrophin, Inc.
Recruiting - verified April 2014

Veterans Service Organizations and MHV

Conditions:   Hypertension;   Hyperlipidemia;   Coronary Artery Disease;   Diabetes Mellitus
Intervention:   Other: Education
Sponsors:   Department of Veterans Affairs;   The American Legion, Department of Wisconsin
Completed - verified April 2014

An Open Label Access Study For Subjects Who Completed A1481156

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Access program
Sponsor:   Pfizer
Temporarily not available - verified April 2014

An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: UT-15C (treprostinil diethanolamine)
Sponsor:   United Therapeutics
Recruiting - verified April 2014

Trial of the Early Combination of Oral Treprostinil With a PDE-5 Inhibitor or ERA in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: UT-15C (treprostinil diethanolamine);   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified April 2014

Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder

Condition:   Attention-deficit/Hyperactivity Disorder
Interventions:   Drug: Lisdexamfetamine dimesylate;   Drug: Methylphenidate Hydrochloride;   Drug: Placebo
Sponsor:   Shire
Active, not recruiting - verified April 2014

Revatio Portal-Pulmonary Arterial Hypertension Trial

Condition:   Portopulmonary Hypertension
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   University Health Network, Toronto
Enrolling by invitation - verified April 2014

A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tadalafil- Tablet
Sponsor:   Eli Lilly and Company
Recruiting - verified April 2014

Educational Training Influence in Patients With PAH(Pulmonary Artery Hypertension) on Inhaled Ventavis Treatment Adherence Evaluated Trough INSIGHT System

Condition:   Pulmonary Arterial Hypertension
Interventions:   Other: Iloprost (Ventavis inhaled, BAYQ6256);   Other: Iloprost (Ventavis inhaled, BAYQ6256)
Sponsors:   Bayer;   Dra. Pilar Escribano Subías - Coordinator - HU 12 de Octubre - Madrid (Spain)
Active, not recruiting - verified April 2014

Glaucoma Eye Drop Instillation: Impact of Education

Condition:   Glaucoma, Open-Angle
Interventions:   Other: Video education on proper eye drop instillation technique;   Other: Placebo video education on healthy eating tips
Sponsor:   Northwestern University
Recruiting - verified April 2014

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

Post-marketing Surveillance for Hypertensive Patients With Diabetes and/or Chronic Kidney Disease

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat CR, BAYA1040)
Sponsor:   Bayer
Completed - verified April 2014

Physical Fitness, Cardiovascular and Brain Health

Condition:   Hypertension
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Relaxation
Sponsors:   University of Texas at Austin;   American Federation for Aging Research
Completed - verified April 2014

Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)

Condition:   Hypertension
Intervention:   Drug: Febuxostat
Sponsor:   University of Utah
Completed - verified February 2014

DVDs About Blood Pressure

Condition:   Hypertension
Interventions:   Other: Story-Telling DVD;   Other: Non-Storytelling DVD
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2014

Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors

Conditions:   Hypertension;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions:   Drug: lisinopril;   Drug: losartan potassium;   Other: laboratory biomarker analysis;   Drug: benazepril hydrochloride;   Drug: ramipril
Sponsor:   Comprehensive Cancer Center of Wake Forest University
Terminated - verified April 2014

Effect of Bosentan in Scleroderma Renal Crisis

Condition:   Scleroderma Renal Crisis
Intervention:   Drug: Bosentan
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Actelion
Recruiting - verified April 2014

Double-blind, Randomized Placebo-controlled Trial of Carvedilol for Early Primary Prophylaxis of Esophageal Varices

Condition:   Cirrhosis
Interventions:   Drug: Carvedilol;   Drug: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed - verified December 2013

Amlodipine And Olmesartan Medoxomil In Hypertensive Filipino Patients

Condition:   Hypertension
Intervention:   Drug: Amlodipine + Olmesartan medoxomil
Sponsor:   Pfizer
Recruiting - verified April 2014

Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of Age

Condition:   Hypertension
Interventions:   Drug: Aliskiren;   Drug: Aliskiren;   Drug: Aliskiren
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Controlling Hypertension Outcomes by Improved Communication & Engagement

Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Four Habits Model
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified April 2014

Post Marketing Observational Study in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: tadalafil
Sponsor:   Eli Lilly and Company
Active, not recruiting - verified April 2014

Study Comparing Two Tapering Strategies of Prednisone in Myasthenia Gravis

Condition:   Myasthenia Gravis
Intervention:   Drug: Prednisone - Azathioprine
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified June 2012

High Blood Pressure and Sleep Apnea in Diabetic Macular Edema

Condition:   Diabetic Retinopathy
Interventions:   Behavioral: high blood pressure treatment;   Behavioral: sleep apnea treatment;   Behavioral: diabetic macular edema treatment
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified April 2014

Gene Expression In Pregnancies Complicated by Preeclampsia

Condition:   Preeclampsia
Interventions:   Procedure: collection of maternal blood specimen prior to delivery;   Procedure: collection of placental cord blood after delivery;   Procedure: collection of placental tissue;   Procedure: collection of strip of decidua from uterine lining from cesarean section deliveries
Sponsors:   University of Rochester;   Mae Stone Goode Foundation Grant
Suspended - verified April 2014

Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil citrate
Sponsor:   Pfizer
Temporarily not available - verified April 2014

The VA Diabetes Trial Follow-up Study (VADT-FS)

Conditions:   Diabetes;   Glycemic Control
Intervention:  
Sponsor:   Department of Veterans Affairs
Active, not recruiting - verified April 2014

Assessment of Efficacy of Vardenafil in Subjects With Erectile Dysfunction and Diabetes, Hypertension or Hyperlipidemia

Condition:   Erectile Dysfunction
Interventions:   Drug: Levitra (Vardenafil, BAY38-9456);   Drug: Tadalafil
Sponsor:   Bayer
Completed - verified October 2013

Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)

Condition:   Pulmonary Hypertension
Intervention:   Drug: SILDENAFIL
Sponsor:   Pfizer
Enrolling by invitation - verified April 2014

Working With Veterans Organizations to Improve Blood Pressure

Condition:   Hypertension
Interventions:   Behavioral: Peer support meetings;   Behavioral: Educational presentations
Sponsors:   Department of Veterans Affairs;   Medical College of Wisconsin;   Veterans of Foreign Wars;   Vietnam Veterans of America;   National Association of Black Veterans;   Korean War Veterans of America;   Disabled American Veterans;   AmVETS;   Jewish War Veterans of the U.S.A.;   American Legion Department of Wisconsin;   Wisconsin Elks Association
Completed - verified April 2014

Pharmacist-led Group Medical Visits to Help With Diabetes Management

Conditions:   Diabetes Mellitus;   Cardiovascular Diseases
Interventions:   Other: Algorithm driven medication titration;   Behavioral: Monitoring;   Behavioral: Group support;   Behavioral: Self efficacy
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Adherence and Intensification of Medications (AIM) Implementation Study

Conditions:   Diabetes;   Hypertension
Intervention:   Behavioral: Clinical pharmacist-based intervention
Sponsors:   Department of Veterans Affairs;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Kaiser Permanente
Completed - verified April 2014

Phenylephrine in Spinal Anesthesia in Preeclamptic Patients

Conditions:   Preeclampsia;   Hypotension
Interventions:   Drug: Ephedrine;   Drug: Phenylephrine
Sponsor:   Northwestern University
Recruiting - verified April 2014

Family-supported Smoking Cessation for Chronically Ill Veterans

Conditions:   Chronic Disease;   Neoplasm;   Cardiovascular Disease;   Pulmonary Disease, Chronic Obstructive;   Diabetes Mellitus;   Hypertension
Interventions:   Behavioral: Family-supported;   Behavioral: Standard Telephone counseling
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Strategies to Maintain Cardiac Risk Control After Discharge From Cardiovascular Risk Reduction Clinic

Conditions:   Diabetes;   Dyslipidemia;   Hypertension;   Coronary Atherosclerosis
Interventions:   Behavioral: Counseling;   Behavioral: Interactive Education;   Behavioral: Group Support;   Procedure: Pharmacologic case management
Sponsors:   Providence VA Medical Center;   Merck Sharp & Dohme Corp.
Completed - verified April 2014

Financial Incentives to Translate ALLHAT Into Practice: A Randomized Trial

Condition:   Hypertension
Interventions:   Behavioral: Physician-level financial incentive;   Behavioral: Group-level financial incentive;   Behavioral: Physician and group-level financial incentives
Sponsors:   Department of Veterans Affairs;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Can Group Visits Improve Outcomes of Veterans With Diabetes

Conditions:   Diabetes;   Hypertension
Intervention:   Other: Diabetes Group Management Visits
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Improving Practice Patterns for the Treatment of Hypertension

Condition:   Hypertension
Interventions:   Behavioral: Provider Education;   Behavioral: Hypertension Alert;   Behavioral: Patient Education
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Hypertension Intervention Nurse Telemedicine Study (HINTS)

Condition:   Hypertension
Interventions:   Behavioral: Nurse Behavioral intervention with Home BP Telemonitoring;   Behavioral: Nurse Medication Management with Home BP Telemonitoring;   Behavioral: Nurse Combined intervention with Home BP Telemonitoring
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Guidelines for Drug Therapy of Hypertension: Multi-Site Implementation

Condition:   Hypertension
Interventions:   Behavioral: ATHENA Decision Support System, An Automated Clinical Decision Support System for Health Care Providers;   Behavioral: Profiling performance
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Genes of Hypertension in African Americans

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsors:   Medical College of Wisconsin;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Novel Approaches in Linkage Analysis for Complex Traits

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsors:   Mayo Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Effectiveness and Cost Impact of a Telecommunications System in COPD

Condition:   Lung Diseases, Obstructive
Intervention:   Procedure: Telephone Monitoring
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

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